AustralieFrV1, Main, Exploration, bibRecord, 002916

Reactions in Nitroimidazole and Methylnitroimidazole Triggered by Low-Energy (0-8 eV) Electrons.

Identifieur interne : 002916 ( Main/Exploration ); précédent : 002915; suivant : 002917

Reactions in Nitroimidazole and Methylnitroimidazole Triggered by Low-Energy (0-8 eV) Electrons.

Auteurs : Katrin Tanzer [Autriche] ; Linda Feketeová [France] ; Benjamin Puschnigg [Autriche] ; Paul Scheier [Autriche] ; Eugen Illenberger [Allemagne] ; Stephan Denifl [Autriche]

Source :

The journal of physical chemistry. A [ 1520-5215 ] ; 2015.

RBID : pubmed:26020684

Descripteurs français

KwdFr :
- Analyse spectrale, Anions (), Hydrogène (), Nitroimidazoles (), Radical hydroxyle (), Radiosensibilisants (), Structure moléculaire, Électrons.
MESH :
- Analyse spectrale, Anions, Hydrogène, Nitroimidazoles, Radical hydroxyle, Radiosensibilisants, Structure moléculaire, Électrons.

English descriptors

KwdEn :
- Anions (chemistry), Electrons, Hydrogen (chemistry), Hydroxyl Radical (chemistry), Molecular Structure, Nitroimidazoles (chemistry), Radiation-Sensitizing Agents (chemistry), Spectrum Analysis.
MESH :
- chemical , chemistry : Anions, Hydrogen, Hydroxyl Radical, Nitroimidazoles, Radiation-Sensitizing Agents.
- Electrons, Molecular Structure, Spectrum Analysis.

Abstract

Low-energy electrons (0-8 eV) effectively decompose 4-nitroimidazole (4NI) and the two methylated isomers 1-methyl-5-nitroimidazole and 1-methyl-4-nitroimidazole via dissociative electron attachment (DEA). The involved unimolecular decompositions range from simple bond cleavages (loss of H(•), formation of NO2(-)) to complex reactions possibly leading to a complete degradation of the target molecule (formation of CN(-), etc.). At energies below 2 eV, the entire rich chemistry induced by DEA is completely quenched by methylation, as demonstrated in a previous communication (Tanzer, K.; Feketeová, L.; Puschnigg, B.; Scheier, P.; Illenberger. E.; Denifl, S. Angew. Chem., Int. Ed. 2014, 53, 12240). The observation that in 4NI neutral radicals and radical anions are formed via DEA at high efficiency already at threshold (0 eV) may have significant implications for the development of nitroimidazole-based radiosensitizers in tumor radiation therapy.

DOI: 10.1021/acs.jpca.5b02721
PubMed: 26020684

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Low-energy electrons (0-8 eV) effectively decompose 4-nitroimidazole (4NI) and the two methylated isomers 1-methyl-5-nitroimidazole and 1-methyl-4-nitroimidazole via dissociative electron attachment (DEA). The involved unimolecular decompositions range from simple bond cleavages (loss of H(•), formation of NO2(-)) to complex reactions possibly leading to a complete degradation of the target molecule (formation of CN(-), etc.). At energies below 2 eV, the entire rich chemistry induced by DEA is completely quenched by methylation, as demonstrated in a previous communication (Tanzer, K.; Feketeová, L.; Puschnigg, B.; Scheier, P.; Illenberger. E.; Denifl, S. Angew. Chem., Int. Ed. 2014, 53, 12240). The observation that in 4NI neutral radicals and radical anions are formed via DEA at high efficiency already at threshold (0 eV) may have significant implications for the development of nitroimidazole-based radiosensitizers in tumor radiation therapy.</div>
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Reactions in Nitroimidazole and Methylnitroimidazole Triggered by Low-Energy (0-8 eV) Electrons.

Reactions in Nitroimidazole and Methylnitroimidazole Triggered by Low-Energy (0-8 eV) Electrons.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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	Serveur d'exploration sur les relations entre la France et l'Australie
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